The role that TGF-β and TGFR play in Angiogenesis

(National Academy of Science, 2013)

 

Like EGFR, TGF-β and TGFR are growth factors and mitogens for endothelial cells (Held-Feindt et al, 2003) expressed on GBM (Choudhury et al, 2010). TGF-β receptors I and II are trans membrane serine/threonine receptor kinases mediating intracellular signaling (Grznil et al, 2011).

TGF-β functions by regulating and inducing the expression of other growth factors: bFGF, PDGF, PDGFR, EGFR (Van Meeteren et al, 2011). It also potentiates the secretion of EGF in GBM as well as up regulating α2 or βintegrin subunit, contributing to endothelial cell motility (Choudhury et al, 2010). ­­­­