The Role that TGF-α, EGF, EGFR play in Glioblastoma Multiforme

(Hooper, 2013)

The epidermal growth factor, stimulating VEGF expression in GBM (Poulaki et al, 2003), and transforming growth factor beta are both RTKs involved in the RAS pathway (Serban et al, 2008). Different forms of the epidermal growth factor are created via mutation, alternative splicing, deletion, genetic rearrangement, and translational alterations (Talasila et al, 2012).

(Shi, 2013)

EGFRvIII and ΔEGFR are over expressed in 60% of all GBMs (Johnson et al, 2012). Both EGFRvIII and ΔEGFR lack a regulatory portion of the extracellular binding site, and function via phosphorylation (Hwang et al, 2012).

(Janku et al, 2010)

 

TGF-α and EGF are mitogens (Rutten et al, 1993) for endothelial cells, promoting cell proliferation, survival, and GBM angiogenesis (Kaur et al, 2005).